Thank you very much for this magnificent article and for revisiting one of humanity’s oldest therapeutic practices—a practice whose biological and metabolic potential deserves far more attention.
Fasting is not merely about abstaining from food; it is about allowing the body to trigger an extraordinary series of physiological mechanisms for adaptation, regulation, and cellular maintenance.
Among its most compelling effects are:
* Activation of autophagy: This promotes the recycling of damaged cellular components and the renewal of intracellular structures.
* Improved insulin sensitivity: This can contribute to better regulation of glucose and energy metabolism.
* Metabolic flexibility: This facilitates the transition from using glucose to mobilizing and oxidizing fatty acids, as well as producing ketone bodies.
* Activation of AMPK and modulation of mTOR: These processes are involved in key signaling pathways related to energy balance, growth, and cellular maintenance.
* Mitochondrial health: This can support adaptive mechanisms and energy efficiency, including the renewal of mitochondria.
* Reduction of inflammation: Some studies show improvements in specific inflammatory and metabolic markers.
* Cardiovascular health: This can help improve blood pressure, triglyceride levels, and other cardiometabolic risk factors.
* Regulation of oxidative stress: This triggers cellular adaptive and defensive responses against oxidative stress.
* Hepatic metabolism: This can help reduce liver fat, particularly in cases where there is an excess of metabolic fat.
* Metabolic and hormonal balance: This alters the signaling of insulin, glucagon, and other hormones involved in the availability and utilization of energy.
It is particularly important, in my view, to revisit the concept that the body requires more than just nutrients to build itself and function; it also needs periods of digestive and metabolic rest to activate its own adaptive and maintenance mechanisms.
For too long, we have defined healthy eating solely in terms of what and how much we consume—forgetting that *when* we eat, and how long we allow our metabolism to rest, can also be of immense biological significance. Understanding its mechanisms opens up a fascinating perspective on prevention and metabolic health—areas involving biological processes that evolution has preserved for millions of years.
Thank you once again for sharing this knowledge and keeping it alive.
PROTEIN, FASTING, CANCER, AND LONGEVITY | VALTER LONGO, PHD
Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology in Los Angeles—a leading center for research on aging and age-related diseases. Dr. Longo also serves as the Director of the Longevity and Cancer Program at the IFOM Institute of Molecular Oncology in Milan, Italy.
In this episode, we explore terms that have become buzzwords in the field of protein research, including IGF-1 and mTOR. We discuss protein requirements for different age groups, the importance of muscle tissue, the benefits of protein consumption, and potential risks. We also cover the fasting-mimicking diet, both for the general population and as an adjunctive treatment for cancer. Specifically, the following topics are covered:
1) Introduction (0:00)
2) Ideal diets for longevity (2:58)
3) Key pathways in aging (9:15)
4) IGF-1 elevation (16:24)
5) Acute vs. chronic IGF-1 elevation (19:46)
6) Dangers of excessive protein consumption (25:11)
7) Impact of exercise on IGF-1 (32:52)
8) Muscle mass and longevity (38:35)
9) Study on high protein intake later in life (41:59)
Fasting is often condemned by modern doctors as dangerous...culminating in anorexia...
And anyone who has worked in customer service environments can remember how their whole day could be coloured by early contact with a garlic pill addict...
It's the needles bearing mRNA unwarranted chemical interventions that we should shun...
Thank you very much for this magnificent article and for revisiting one of humanity’s oldest therapeutic practices—a practice whose biological and metabolic potential deserves far more attention.
Fasting is not merely about abstaining from food; it is about allowing the body to trigger an extraordinary series of physiological mechanisms for adaptation, regulation, and cellular maintenance.
Among its most compelling effects are:
* Activation of autophagy: This promotes the recycling of damaged cellular components and the renewal of intracellular structures.
* Improved insulin sensitivity: This can contribute to better regulation of glucose and energy metabolism.
* Metabolic flexibility: This facilitates the transition from using glucose to mobilizing and oxidizing fatty acids, as well as producing ketone bodies.
* Activation of AMPK and modulation of mTOR: These processes are involved in key signaling pathways related to energy balance, growth, and cellular maintenance.
* Mitochondrial health: This can support adaptive mechanisms and energy efficiency, including the renewal of mitochondria.
* Reduction of inflammation: Some studies show improvements in specific inflammatory and metabolic markers.
* Cardiovascular health: This can help improve blood pressure, triglyceride levels, and other cardiometabolic risk factors.
* Regulation of oxidative stress: This triggers cellular adaptive and defensive responses against oxidative stress.
* Hepatic metabolism: This can help reduce liver fat, particularly in cases where there is an excess of metabolic fat.
* Metabolic and hormonal balance: This alters the signaling of insulin, glucagon, and other hormones involved in the availability and utilization of energy.
It is particularly important, in my view, to revisit the concept that the body requires more than just nutrients to build itself and function; it also needs periods of digestive and metabolic rest to activate its own adaptive and maintenance mechanisms.
For too long, we have defined healthy eating solely in terms of what and how much we consume—forgetting that *when* we eat, and how long we allow our metabolism to rest, can also be of immense biological significance. Understanding its mechanisms opens up a fascinating perspective on prevention and metabolic health—areas involving biological processes that evolution has preserved for millions of years.
Thank you once again for sharing this knowledge and keeping it alive.
PROTEIN, FASTING, CANCER, AND LONGEVITY | VALTER LONGO, PHD
Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Sciences and Director of the Longevity Institute at the University of Southern California’s Leonard Davis School of Gerontology in Los Angeles—a leading center for research on aging and age-related diseases. Dr. Longo also serves as the Director of the Longevity and Cancer Program at the IFOM Institute of Molecular Oncology in Milan, Italy.
In this episode, we explore terms that have become buzzwords in the field of protein research, including IGF-1 and mTOR. We discuss protein requirements for different age groups, the importance of muscle tissue, the benefits of protein consumption, and potential risks. We also cover the fasting-mimicking diet, both for the general population and as an adjunctive treatment for cancer. Specifically, the following topics are covered:
1) Introduction (0:00)
2) Ideal diets for longevity (2:58)
3) Key pathways in aging (9:15)
4) IGF-1 elevation (16:24)
5) Acute vs. chronic IGF-1 elevation (19:46)
6) Dangers of excessive protein consumption (25:11)
7) Impact of exercise on IGF-1 (32:52)
8) Muscle mass and longevity (38:35)
9) Study on high protein intake later in life (41:59)
10) How to get tested for IGF-1 (48:03)
11) Low IGF-1 and cognitive decline (49:54)
12) IGF-1 resistance (53:00)
13) Mendelian randomization studies (54:38)
14) Fasting-mimicking diet (59:21)
15) Fasting and cancer (1:16:03)
16) Ketogenic diet and cancer (1:27:51)
17) Conclusion (1:32:15)
https://theproof.com/protein-fasting-cancer-and-longevity-valter-longo-phd/
It has to be said...
Fasting is often condemned by modern doctors as dangerous...culminating in anorexia...
And anyone who has worked in customer service environments can remember how their whole day could be coloured by early contact with a garlic pill addict...
It's the needles bearing mRNA unwarranted chemical interventions that we should shun...
Discipline!!!