Kidney health depends on much more than just the kidney’s filtration capacity. It is also important to preserve the cellular environment, proper hydration, and the balance of minerals and electrolytes.
Research by Gerald Pollack on "structured water" (or "EZ water") and the theories proposed by Gilbert Ling invite us to explore the role that the organization of water plays within cells and tissues. This is an intriguing area of study.
While such research continues to evolve, there are other, more well-established preventive measures: maintaining adequate hydration—avoiding both dehydration and fluid overload; moderating salt intake, as high sodium consumption contributes to hypertension and can increase the workload on the kidneys; and reducing exposure to nephrotoxic substances, including certain medications, heavy metals, and environmental pollutants.
It is also advisable to avoid the indiscriminate use of anti-inflammatory drugs, such as ibuprofen, and to consult with a physician regarding any medications that could potentially harm the kidneys.
Renal fibrosis is the result of persistent injury and inflammation. Therefore, protecting kidney tissue requires addressing the factors that can cause damage, managing blood pressure, and maintaining metabolic balance.
While the biology of water within our cells warrants greater attention, it is essential to remember that proper hydration, reduced salt intake, and minimized exposure to toxins remain the most robustly supported preventive measures. 1. KDIGO – Medications and renal toxicity. Recommendations for avoiding drugs that may be harmful to the kidneys.
Our Creator designed the human body to function by eating specific foods to nourish it.. We are a Species like every other Species and have Species-Specific Foods. Do we eat the foods that humans are supposed to eat? One generation after another eats in the same manner as the previous generation... producing the same ill effects. 95% of the time...food or something else which has entered the digestive system... is the culprit. Today, we must add into the equation...drug and vaccines, which damage the internal cells, glands and organs. I ask for guidance...and this is the information that I am receiving. Our Creator did not give us a manual...and we have lost all our instincts. Animals in the wild still have them. and know what their species needs.
It is concerning that we have delegated our health and our intuition to social inertia and to the food and pharmaceutical industries—forgetting that human biology does not negotiate with fads, commercial commitments, or interests unrelated to physiology. For millennia, every species has found within its environment the precise elements needed to sustain its homeostasis and vitality; yet, modern humans have normalized a pattern of consumption that is entirely misaligned with their evolutionary design.
The result is plain to see: a chronic, intergenerational suffering that is accepted as inevitable, when in reality it is the cumulative product of the continuous introduction of foreign substances—substances that overwhelm our organs of elimination, inflame the intestinal mucosa, and disrupt the delicate cellular balance. Regaining clarity and genuine health requires, quite simply, stepping off "autopilot," questioning nutritional dogmas born of convenience, and reconnecting with rigor, simplicity, and an absolute respect for what we choose to let cross our digestive barrier.☀️🙏🏼
As a grandparent of twins who were diagnosed at birth with the genetic marker(s) for cystic fibrosis (CF), this essay makes me curious about the degree to which the concepts in the essay apply to CF. The essay characterizes the PKD and PLD conditions as a LOSS of water-cell structure, implying an amorphous, watery result rather than a healthy "gel." But CF is characterized by what seems the opposite: the mucosal secretions of the lungs becoming too dense, creating congestion and breeding-grounds for bacteria.
I'd be interested to hear your (UnB) speculations on the applications of the ideas in this essay to the CF condition.
My grandchildren, BTW, just crossed their 10th birthday and have had ZERO indications of the development of CF, thank God! BUT they've been taking a "trivalent" (3-in-one) drug that is supposed to mitigate the CF for 3+ years and costs about $250k per year!
Your observation is very interesting. At first glance, cystic fibrosis appears to present the opposite phenomenon to the one described in the essay on polycystic kidney disease: instead of a loss of structural integrity, we see mucus that is excessively thick and dehydrated.
However, there is an important common link: the regulation of water and electrolytes across cell membranes.
In cystic fibrosis, mutations in the *CFTR* gene disrupt the transport of chloride and bicarbonate. This alters the movement of water toward the surface of the airways, causing the mucus to lose hydration and become viscous, which hinders the clearance of bacteria and particles by the cilia.
Therefore, although the physical outcome may appear opposite, in both cases it is worth studying how disruptions in water balance can alter the physical properties of tissues and their secretions.
Regarding the "trivalent" medication, you are likely referring to the combination of elexacaftor, tezacaftor, and ivacaftor (marketed as Trikafta or Kaftrio). It is an innovative treatment that targets the defective CFTR protein, improving its function and promoting the hydration of secretions. It is not merely a medication to manage symptoms; rather, it acts directly on the molecular mechanism of the disease.
Most importantly, it is excellent news that your grandchildren have reached the age of ten without any clinical manifestations. I hope they continue to do well for many years to come.
1. Mechanism of cystic fibrosis – Cystic Fibrosis Foundation. Explains how CFTR alterations affect the transport of chloride and water, leading to dehydrated mucus and impaired bacterial clearance.
Kidney health depends on much more than just the kidney’s filtration capacity. It is also important to preserve the cellular environment, proper hydration, and the balance of minerals and electrolytes.
Research by Gerald Pollack on "structured water" (or "EZ water") and the theories proposed by Gilbert Ling invite us to explore the role that the organization of water plays within cells and tissues. This is an intriguing area of study.
While such research continues to evolve, there are other, more well-established preventive measures: maintaining adequate hydration—avoiding both dehydration and fluid overload; moderating salt intake, as high sodium consumption contributes to hypertension and can increase the workload on the kidneys; and reducing exposure to nephrotoxic substances, including certain medications, heavy metals, and environmental pollutants.
It is also advisable to avoid the indiscriminate use of anti-inflammatory drugs, such as ibuprofen, and to consult with a physician regarding any medications that could potentially harm the kidneys.
Renal fibrosis is the result of persistent injury and inflammation. Therefore, protecting kidney tissue requires addressing the factors that can cause damage, managing blood pressure, and maintaining metabolic balance.
While the biology of water within our cells warrants greater attention, it is essential to remember that proper hydration, reduced salt intake, and minimized exposure to toxins remain the most robustly supported preventive measures. 1. KDIGO – Medications and renal toxicity. Recommendations for avoiding drugs that may be harmful to the kidneys.
https://kdigo.org/wp-content/uploads/2024/03/KDIGO-2024-CKD-Guideline.pdf
2. National Kidney Foundation – Hydration and the kidneys. The importance of maintaining adequate hydration.
https://www.kidney.org/hydrate
3. Renal fibrosis – Scientific review. Mechanisms of injury and inflammation that promote fibrosis in kidney tissue. https://pmc.ncbi.nlm.nih.gov/articles/PMC7404113
The body knows what to do, but man thinks he knows better, but what he thinks he knows just keeps making it worse !!!
Our Creator designed the human body to function by eating specific foods to nourish it.. We are a Species like every other Species and have Species-Specific Foods. Do we eat the foods that humans are supposed to eat? One generation after another eats in the same manner as the previous generation... producing the same ill effects. 95% of the time...food or something else which has entered the digestive system... is the culprit. Today, we must add into the equation...drug and vaccines, which damage the internal cells, glands and organs. I ask for guidance...and this is the information that I am receiving. Our Creator did not give us a manual...and we have lost all our instincts. Animals in the wild still have them. and know what their species needs.
It is concerning that we have delegated our health and our intuition to social inertia and to the food and pharmaceutical industries—forgetting that human biology does not negotiate with fads, commercial commitments, or interests unrelated to physiology. For millennia, every species has found within its environment the precise elements needed to sustain its homeostasis and vitality; yet, modern humans have normalized a pattern of consumption that is entirely misaligned with their evolutionary design.
The result is plain to see: a chronic, intergenerational suffering that is accepted as inevitable, when in reality it is the cumulative product of the continuous introduction of foreign substances—substances that overwhelm our organs of elimination, inflame the intestinal mucosa, and disrupt the delicate cellular balance. Regaining clarity and genuine health requires, quite simply, stepping off "autopilot," questioning nutritional dogmas born of convenience, and reconnecting with rigor, simplicity, and an absolute respect for what we choose to let cross our digestive barrier.☀️🙏🏼
Agreed! The simple truth.. It is imperative to do some research, before accepting information coming from those who stand to profit from it.
As a grandparent of twins who were diagnosed at birth with the genetic marker(s) for cystic fibrosis (CF), this essay makes me curious about the degree to which the concepts in the essay apply to CF. The essay characterizes the PKD and PLD conditions as a LOSS of water-cell structure, implying an amorphous, watery result rather than a healthy "gel." But CF is characterized by what seems the opposite: the mucosal secretions of the lungs becoming too dense, creating congestion and breeding-grounds for bacteria.
I'd be interested to hear your (UnB) speculations on the applications of the ideas in this essay to the CF condition.
My grandchildren, BTW, just crossed their 10th birthday and have had ZERO indications of the development of CF, thank God! BUT they've been taking a "trivalent" (3-in-one) drug that is supposed to mitigate the CF for 3+ years and costs about $250k per year!
Your observation is very interesting. At first glance, cystic fibrosis appears to present the opposite phenomenon to the one described in the essay on polycystic kidney disease: instead of a loss of structural integrity, we see mucus that is excessively thick and dehydrated.
However, there is an important common link: the regulation of water and electrolytes across cell membranes.
In cystic fibrosis, mutations in the *CFTR* gene disrupt the transport of chloride and bicarbonate. This alters the movement of water toward the surface of the airways, causing the mucus to lose hydration and become viscous, which hinders the clearance of bacteria and particles by the cilia.
Therefore, although the physical outcome may appear opposite, in both cases it is worth studying how disruptions in water balance can alter the physical properties of tissues and their secretions.
Regarding the "trivalent" medication, you are likely referring to the combination of elexacaftor, tezacaftor, and ivacaftor (marketed as Trikafta or Kaftrio). It is an innovative treatment that targets the defective CFTR protein, improving its function and promoting the hydration of secretions. It is not merely a medication to manage symptoms; rather, it acts directly on the molecular mechanism of the disease.
Most importantly, it is excellent news that your grandchildren have reached the age of ten without any clinical manifestations. I hope they continue to do well for many years to come.
1. Mechanism of cystic fibrosis – Cystic Fibrosis Foundation. Explains how CFTR alterations affect the transport of chloride and water, leading to dehydrated mucus and impaired bacterial clearance.
https://www.cff.org/research-clinical-trials/research-mucus
2. Diagnosis of cystic fibrosis – Cystic Fibrosis Foundation. Distinguishes between a positive genetic marker, an abnormal newborn screening result, and a confirmed diagnosis. https://www.cff.org/medical-professionals/cf-diagnosis-clinical-care-guidelines
thank you !!